kassikatsed linnugripiga ja levikuviisid
väidetavalt üks oluline uuring, nakatati kasse kõikvõimalikel viisidel linnugrippi - ja leiti, et nakatuvad igat moodi ..
ja kuna kass on imetaja :D ja inimene on ka imetaja - siis annab infot ka inimeste kohta
kokkuvõtteks - et ei nakka see gripp midagi ainult aevastuse kaudu, vaid märksa tõhusamalt
To assess the spread of H5N1 influenza virus in mammalian hosts,
Rimmelzwaan et al. examined cats infected via the respiratory tract,
via the digestive tract (by feeding on infected chicks), or by close
contact with respiratory-infected cats. The researchers, led by Dr.
Thijs Kuiken, then examined mucous membranes (throat, nasal, and
rectal swabs) and organ systems (respiratory, digestive, nervous,
cardiovascular, urinary, lymphoid, and endocrine) for the presence of
virus and viral protein.
As expected, all cats were infected with H5N1 virus and exhibited
clinical signs of disease (fever, lethargy, labored breathing, etc.),
and virus was detected in throat, nasal, and rectal swabs, regardless
of the original site of infection. Most interesting, virus spread
throughout the organ systems with virus being found in respiratory
and digestive tracts, liver, kidney, heart, brain, and lymph nodes.
Furthermore, examination of infected tissues revealed cellular damage
at sites containing viral proteins, providing an explanation for the
increased severity of disease in humans.
These data underscore the potential for influenza virus to spread not
only from the respiratory tract but also from the digestive and
urinary tracts, greatly increasing the possible routes of mammalian
transmission. Systemic disease has long been known to occur in birds,
with the fecal-oral route of transmission being most important.
However, this is the 1st demonstration of systemic replication in
cats, providing a cautionary tale for humans regarding how influenza
is spread and how the disease presents itself.
.. "H5N1 virus infection needs to be included
in the differential diagnosis of a broader range of clinical
presentations than is currently done." In addition better
understanding of the mechanisms of spread, including possible
fecal-oral route in humans, "may limit the risk of H5N1 virus
developing into a pandemic influenza virus."